cyclobenzaprine是什么意思？用法、例句？Saturday challenge 丨 不服来战

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每周六，一个病例，一道题，一个知识点，掌握专业医学英语

如果觉得每周一题不过瘾，猛戳文末阅读原文哦！

这里的题库是美国医学生都看的经典题库，每道题都是经过大咖审核，答案中的评述可能比题目还长，融合了最新的医学进展。可谓是一篇小综述。

A19-year-oldmanpresentsforevaluationofarunnynoseandtinglingofhisforeheadthatstarted6monthsago.Heattributeshissymptomstoatrackingdevicethegovernmentimplantedinhisbrainaspartofaprojecttodevelopremotemindcontrol.Heclaimsthedevicerunscommentariesonhisdailyactivities,insertsnewthoughtswhiledeletinghisown,andbroadcastshisideastogovernmentagencies.

Duringtheinterview,thepatientbecomesacutelyagitatedandthreateningtowardstaff.Adecisionismadetotreattheagitationwithintramuscularhaloperidol.

Whichoneofthefollowingmedicationsisindicatedtoreducetheriskofacutedystoniainthispatient?

Dystoniaresultingfromafirst-generationantipsychoticdrug,suchashaloperidol,canbepreventedbycoadministeringananticholinergicdrug,suchasbenztropine.

Acutedrug-induceddystoniaischaracterizedbyasustainedabnormalpostureormusclespasmthatdevelopsafterreceiptofadopamine-blockingagent,suchasanantipsychotic,antiemetic,orantidepressant.Riskfactorsforacutedrug-induceddystoniaincludeyoungage,malesex,neuroleptic-naivestatus,cocaineuse,andahistoryofacutedystonia.High-potencyantipsychoticdrugs,suchashaloperidol,causedystoniamorefrequentlythanlow-potencydrugs.

Aprophylacticanticholinergicdrug,suchasbenztropine,isrecommendedwhenfirst-generationantipsychoticdrugsareinitiatedinpatientswhoareathighriskfordevelopingdrug-induceddystonia,particularlyneuroleptic-naivepatientswhoareacutelypsychotic.

Dystoniaisapotentiallyfrighteningsideeffectthatmayscareapatientawayfromcontinuingwiththeneededtreatment,sobenztropinetohelpreducetheriskofdystoniaisparticularlyprudentwheninitiatingafirst-generationantipsychotictoanacutelyagitatedpsychoticpatient.

Benzodiazepines(e.g.,alprazolam)andbeta-blockers(e.g.,propranolol)areusedtomitigatetheextrapyramidalsideeffectsofdopamine-blockingagents,buttheyarenotindicatedforpreventingacutedystonicreaction.

Musclerelaxants(e.g.,cyclobenzaprine)andanticonvulsants(e.g.,carbamazepine)arenotindicatedtopreventortreattheextrapyramidalsideeffectsoffirst-generationantipsychotics.

vanHartenPNetal.Acutedystoniainducedbydrugtreatment.BMJ1999Sep3;319:623.

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如果觉得每周一题不过瘾，扫描海报二维码或猛戳文末阅读原文哦！

这里是靠谱的医学词汇平台，有趣，有料。

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